Michele's paper "Elucidating gene-by-environment interactions associated with differential susceptibility to chemical exposure" was cited in the NIEHS newsletter as a Paper of the Month!
Blog posts
Updated ToxPi version (v 2.1) available at www.toxpi.org
A major update to the ToxPi interface (version 2.1) is now available at:
This update includes major speed improvements (especially noticeable when clustering large datasets), the ability to zoom/pan on cluster dendrograms, as well as other refinements for GUI users.
Marissa's ASHG submission awarded "Reviewer's Choice"
Marissa Kosnik's submission to the 2018 American Society of Human Genetics (ASHG) meeting in San Diego has been selected as a Reviewers’ Choice Abstract. It means that the abstract scored in the top 10% of poster abstracts as determined by the reviewers’ score.
Elucidating Gene-by-Environment Interactions Associated with Differential Susceptibility to Chemical Exposure (2018) EHP
Full paper:
https://ehp.niehs.nih.gov/EHP2662/
PubMed:
https://www.ncbi.nlm.nih.gov/pubmed/29968567
News releases and press coverage:
https://news.ncsu.edu/2018/06/reif-genes-environment/
https://www.sciencedaily.com/releases/2018/06/180629114700.htm
https://globalhealthne…
Kim To presents at BioLunch Seminar Series
Kim To presented a seminar entitled "Developmental Toxicity of Engineered Nanomaterials in Zebrafish Embryos" at the BioLunch Seminar Series.
Characterizing the effects of missing data and evaluating imputation methods for chemical prioritization applications using ToxPi (2018) BioData Mining
Kimberly T. To, Rebecca C. Fry, David M. Reif. Characterizing the effects of missing data and evaluating imputation methods for chemical prioritization applications using ToxPi. BioData Mining. 2018.
https://rdcu.be/XYtJ
Reif appointed to National Academy of Sciences (NAS) committee
Scoping Plan to Assess the Hazards of Organohalogen Flame Retardants
https://www8.nationalacademies.org/cp/CommitteeView.aspx?key=49937
Confirmation of high-throughput screening data and novel mechanistic insights into VDR-xenobiotic interactions by orthogonal assays (2018) Scientific Reports
Mahapatra D, Franzosa JA, Roell K, Kuenemann MA, Houck KA, Reif DM, Fourches
D, Kullman SW. Confirmation of high-throughput screening data and novel
mechanistic insights into VDR-xenobiotic interactions by orthogonal assays. Sci
Rep. 2018 Jun 11;8(1):8883. doi: 10.1038/s41598-018-27055-3. PubMe…
Kyle Roell successfully defends his PhD!
Kyle Roell successfully defended his PhD, entitled "Statistical Methods for Assessing the Genetic Etiology of Synergistic Drug Interactions".
Dr. Kyle Roell is currently a postdoc with Stephanie Engel in the Department of Epidemiology at UNC Chapel Hill.
Kosnik presents at Toxicology Seminar Series
Marissa Kosnik presented a seminar at the Toxicology Seminar Series, entitled "Integration of disparate data to elucidate connections between
environmental factors and human health outcomes".
ToxPi Graphical User Interface 2.0: Dynamic exploration, visualization, and sharing of integrated data models (2018) BMC Bioinformatics
Marvel SW, To K, Grimm FA, Wright FA, Rusyn I, Reif DM. ToxPi Graphical User Interface 2.0: Dynamic exploration, visualization, and sharing of integrated data models. BMC Bioinformatics. 2018 Mar 5;19(1):80. doi: 10.1186/s12859-018-2089-2. PubMed PMID: 29506467.
National Academies meeting: "Informing Environmental Health Decisions Through Data Integration"
David Reif was a moderator and member of the planning committee for the National Academy of Sciences workshop "Informing Environmental Health Decisions Through Data Integration".
The workshop brought together thought leaders from diverse fields to explore the promise and potential pitfalls of e…
Population genetic diversity in zebrafish lines (2018) Mammalian Genome
Balik-Meisner M, Truong L, Scholl EH, Tanguay RL, Reif DM. Population genetic diversity in zebrafish lines. Mamm Genome. 2018 Jan 24. doi: 10.1007/s00335-018-9735-x. [Epub ahead of print] PubMed PMID: 29368091.
https://www.ncbi.nlm.nih.gov/pubmed/29368091
Reif presents SOT webinar "How to Present a Code-Based Course to Students with No Previous Coding Experience"
David Reif presented as part of a webinar organized by the Society of Toxicology (SOT) Undergraduate Educator Network.
More details can be found here, under the title "Don’t Sweat It…Three Dry Labs for Undergraduate Toxicology Programs":
Flash Report: SEAZIT Ontologies Workshop
A report on the SEAZIT (Systematic Evaluation of the Application of Zebrafish in Toxicology) Ontologies Workshop has been published:
https://ntp.niehs.nih.gov/iccvam/methods/dev-repro/ontologies-wksp-rept-2017.pdf
Reif serves as Working Group member for the World Health Organization's (WHO) International Agency for Research on Cancer (IARC) monograph on Benzene
David Reif was a member of the Working Group that drew experts from around the world to a meeting in Lyon, France in order to evaluate the carcinogenicity of Benzene.
Summaries of the final evaluations are available in the Lancet Oncology article. The detailed assessments will be published as …
Reif presents at Environmental Mutagenesis & Genomics Society
David presented a seminar at the annual meeting of the Environmental Mutagenesis & Genomics Society (EMGS), entitled: "Gene-Environment Interactions Associated with Differential Susceptibility to Chemical Exposure".
Michele Balik-Meisner successfully defends her PhD!
Michele Balik-Meisner successfully defended her doctoral dissertation, entitled "Gene-by-Environment Interactions Associated with Inter-Individual Variation in Response to Chemical Exposure".
Michele will continue her research as a Bioinformaticist at Sciome.
Congratulations!!!
Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups (2017) ALTEX
WA Chiu, KZ Guyton, MT Martin, DM Reif, I Rusyn. ALTEX. 2017.
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