Kimberly T. To, Rebecca C. Fry, David M. Reif. Characterizing the effects of missing data and evaluating imputation methods for chemical prioritization applications using ToxPi. BioData Mining. 2018.
https://rdcu.be/XYtJ
Blog posts
Reif appointed to National Academy of Sciences (NAS) committee
Scoping Plan to Assess the Hazards of Organohalogen Flame Retardants
https://www8.nationalacademies.org/cp/CommitteeView.aspx?key=49937
Confirmation of high-throughput screening data and novel mechanistic insights into VDR-xenobiotic interactions by orthogonal assays (2018) Scientific Reports
Mahapatra D, Franzosa JA, Roell K, Kuenemann MA, Houck KA, Reif DM, Fourches
D, Kullman SW. Confirmation of high-throughput screening data and novel
mechanistic insights into VDR-xenobiotic interactions by orthogonal assays. Sci
Rep. 2018 Jun 11;8(1):8883. doi: 10.1038/s41598-018-27055-3. PubMe…
Kyle Roell successfully defends his PhD!
Kyle Roell successfully defended his PhD, entitled "Statistical Methods for Assessing the Genetic Etiology of Synergistic Drug Interactions".
Dr. Kyle Roell is currently a postdoc with Stephanie Engel in the Department of Epidemiology at UNC Chapel Hill.
Kosnik presents at Toxicology Seminar Series
Marissa Kosnik presented a seminar at the Toxicology Seminar Series, entitled "Integration of disparate data to elucidate connections between
environmental factors and human health outcomes".
ToxPi Graphical User Interface 2.0: Dynamic exploration, visualization, and sharing of integrated data models (2018) BMC Bioinformatics
Marvel SW, To K, Grimm FA, Wright FA, Rusyn I, Reif DM. ToxPi Graphical User Interface 2.0: Dynamic exploration, visualization, and sharing of integrated data models. BMC Bioinformatics. 2018 Mar 5;19(1):80. doi: 10.1186/s12859-018-2089-2. PubMed PMID: 29506467.
National Academies meeting: "Informing Environmental Health Decisions Through Data Integration"
David Reif was a moderator and member of the planning committee for the National Academy of Sciences workshop "Informing Environmental Health Decisions Through Data Integration".
The workshop brought together thought leaders from diverse fields to explore the promise and potential pitfalls of e…
Population genetic diversity in zebrafish lines (2018) Mammalian Genome
Balik-Meisner M, Truong L, Scholl EH, Tanguay RL, Reif DM. Population genetic diversity in zebrafish lines. Mamm Genome. 2018 Jan 24. doi: 10.1007/s00335-018-9735-x. [Epub ahead of print] PubMed PMID: 29368091.
https://www.ncbi.nlm.nih.gov/pubmed/29368091
Reif presents SOT webinar "How to Present a Code-Based Course to Students with No Previous Coding Experience"
David Reif presented as part of a webinar organized by the Society of Toxicology (SOT) Undergraduate Educator Network.
More details can be found here, under the title "Don’t Sweat It…Three Dry Labs for Undergraduate Toxicology Programs":
Flash Report: SEAZIT Ontologies Workshop
A report on the SEAZIT (Systematic Evaluation of the Application of Zebrafish in Toxicology) Ontologies Workshop has been published:
https://ntp.niehs.nih.gov/iccvam/methods/dev-repro/ontologies-wksp-rept-2017.pdf
Reif serves as Working Group member for the World Health Organization's (WHO) International Agency for Research on Cancer (IARC) monograph on Benzene
David Reif was a member of the Working Group that drew experts from around the world to a meeting in Lyon, France in order to evaluate the carcinogenicity of Benzene.
Summaries of the final evaluations are available in the Lancet Oncology article. The detailed assessments will be published as …
Reif presents at Environmental Mutagenesis & Genomics Society
David presented a seminar at the annual meeting of the Environmental Mutagenesis & Genomics Society (EMGS), entitled: "Gene-Environment Interactions Associated with Differential Susceptibility to Chemical Exposure".
Michele Balik-Meisner successfully defends her PhD!
Michele Balik-Meisner successfully defended her doctoral dissertation, entitled "Gene-by-Environment Interactions Associated with Inter-Individual Variation in Response to Chemical Exposure".
Michele will continue her research as a Bioinformaticist at Sciome.
Congratulations!!!
Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups (2017) ALTEX
WA Chiu, KZ Guyton, MT Martin, DM Reif, I Rusyn. ALTEX. 2017.
Reif presents at OpenTox conference
David Reif presented at the 2017 OpenTox USA meeting. Thanks to Barry Hardy and Noffisat Oki for the invitation to speak!
His seminar was entitled "Implications of Population Genetic Diversity for Safety Assessment."
Transgenerational inheritance of neurobehavioral and physiological deficits from developmental exposure to benzo [a] pyrene in zebrafish (2017) Toxicology and Applied Pharmacology
Knecht AL, Truong L, Marvel SW, Reif DM, Garcia A, Lu C, Simonich MT, Teeguarden JG, Tanguay RL. Transgenerational inheritance of neurobehavioral and physiological deficits from developmental exposure to benzo[a]pyrene in zebrafish. Toxicol Appl Pharmacol. 2017 Jun 3;329:148-157. doi: 10.1016/…
Reif presents at International Neurotoxicology Association meeting in Brazil
David Reif presented at the joint meeting of the International Neurotoxicology Association & Neurotoxicity Society in Florianopolis, Brazil.
The seminar was entitled "Developing an Integrated Testing Strategy: Analytical methods to distill useful information from high-throughput screening of ch…
Reif, Kosnik, and Hoppin present at the University of Wollongong, Australia
David Reif, Marissa Kosnik, and Jane Hoppin traveled to Australia to present and collaborate with researchers at the University of Wollongong. The trip was sponsored by a grant from the University Global Partnership Network (UGPN). Our hosts were Thomas Astell-Burt and Xiaoqi Feng, who direct the Po…
An introduction to terminology and methodology of chemical synergy -perspectives from across disciplines (2017) Frontiers in Pharmacology
K Roell, D Reif, A Motsinger-Reif (2017) An introduction to terminology and methodology of chemical synergy-perspectives from across disciplines. Frontiers in Pharmacology.