Reif Lab

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A chemical-biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives (2016) Green Chemistry

May 16, 2016

F. A. Grimm, Y. Iwata, O. Sirenko, G. A. Chappell, F. A. Wright, D. M. Reif, J. Braisted, D. L. Gerhold, J. M. Yeakley, P. Shepard, B. Seligmann, T. Roy, P. J. Boogaard, H. B. Ketelslegers, A. M. Rohde and I. Rusyn, Green Chem., 2016, DOI: 10.1039/C6GC01147K.

Open Access / Freely-available:

ht…

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Advancing Exposure Science through Chemical Data Curation and Integration in the Comparative Toxicogenomics Database (2016) Environmental Health Perspectives

May 12, 2016
Grondin CJ, Davis AP, Wiegers TC, King BL, Wiegers JA, Reif DM, Hoppin JA,
Mattingly CJ. Advancing Exposure Science through Chemical Data Curation and
Integration in the Comparative Toxicogenomics Database. Environ Health Perspect. 
2016 May 12. [Epub ahead of print] PubMed PMID: 27170236.

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Reif is invited expert at "Aggregate Exposure Pathway" workshop

May 11, 2016

David Reif was an invited expert at the U.S. EPA "Expert Workshop on Aggregate Exposure Pathway: A Conceptual Framework to Advance Exposure Science Research and Complete the Source-to-Outcome Continuum for Risk Assessment".

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Aggregate entropy scoring for quantifying activity across endpoints with irregular correlation structure (2016) Reproductive Toxicology

April 27, 2016
Zhang G, Marvel S, Truong L, Tanguay RL, Reif DM. Aggregate entropy scoring
for quantifying activity across endpoints with irregular correlation structure.
Reprod Toxicol. 2016 Apr 27;62:92-99. doi: 10.1016/j.reprotox.2016.04.012. [Epub 
ahead of print] PubMed PMID: 27132190.

Selected as cov…

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Meisner gives invited seminar at The College of New Jersey

April 27, 2016

Michele Meisner gave an invited seminar at The College of New Jersey, entitled "Elucidating Gene by Environment Interactions Associated with Interindividual Variation in Response to Chemical Exposure".

The seminar, sponsored by the Departments of Mathematics and Statistics, included both a resear…

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European Chemicals Agency workshop on "New Approach Methodologies in Regulatory Science"

April 18, 2016

David Reif presented at an invited workshop from the European Chemicals Agency (ECHA) in Helsinki, Finland on "New Approach Methodologies in Regulatory Science".

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Reif named Associate Editor at Environmental Health Perspectives

April 8, 2016

David Reif has been named to the Board of Associate Editors of the journal Environmental Health Perspectives 

 

The mission of Environmental Health Perspectives (EHP) is to serve as a forum for the discussion of the interrelationships between the environment and human health by publishing…

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Bioinformatics short course at Fayetteville State University RISE program

March 19, 2016

Nadia Singh, Dahlia Nielsen, and David Reif presented a one-day short course on Bioinformatics at Fayetteville State University as part of their NIH-funded Research Initiative for Scientific Enhancement (RISE) program to increase the number of well-prepared FSU biology, chemistry and psychology mi…

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Prioritizing Environmental Chemicals for Obesity and Diabetes Outcomes Research: A Screening Approach Using ToxCast High Throughput Data (2016) Environmental Health Perspectives

March 15, 2016
Auerbach S, Filer D, Reif D, Walker V, Holloway AC, Schlezinger J, Srinivasan 
S, Svoboda D, Judson R, Bucher JR, Thayer KA. Prioritizing Environmental
Chemicals for Obesity and Diabetes Outcomes Research: A Screening Approach Using 
ToxCast High Throughput Data. Environ Health Perspect. 2016 M…

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Tanguay + Reif labs awarded new Systems Toxicology grant!

January 7, 2016

The Environmental Protection Agency (EPA) has awarded a 3-year grant to fund a collaboration between Oregon State University (Robert Tanguay, Jane La Du, Mike Simonich, Chris Sullivan) and North Carolina State University (David Reif) entitled "System Toxicological Approaches to Define Flame Retardan…

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Michele Meisner awarded scholarship from the Foundation for Toxicology and Agromedicine

December 29, 2015

Michele Meisner has been awarded a scholarship from the Foundation for Toxicology and Agromedicine.  

The award is designed to enrich the graduate experience.

 

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Kimberly To joins the Reif Lab!

November 8, 2015

Bio

Using ToxCastâ„¢ Data to Reconstruct Dynamic Cell State Trajectories and Estimate Toxicological Points of Departure (2015) EHP

October 19, 2015

Shah I, Setzer RW, Jack J, Houck KA, Judson RS, Knudsen TB, Liu J, Martin MT, Reif DM, Richard AM, Thomas RS, Crofton KM, Dix DJ, Kavlock RJ. Using ToxCast™ Data to Reconstruct Dynamic Cell State Trajectories and Estimate Toxicological Points of Departure. (2015) Environ Health Perspect; http://d…

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Reif co-authors National Academy of Sciences (NAS) report "Application of Modern Toxicology Approaches for Predicting Acute Toxicity for Chemical Defense"

August 24, 2015

David Reif served as a member of an expert committee that authored the report "Application of Modern Toxicology Approaches for Predicting Acute Toxicity for Chemical Defense". 

The official citation is:

National Academies of Sciences, Engineering, and Medicine. Application of Modern Toxicolo…

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Reif part of multi-institute research team awarded EPA grant

August 17, 2015

The Environmental Protection Agency (EPA) has awarded a $6 million grant to fund a multi-institutional collaboration between the Texas A&M College of Veterinary Medicine & Biomedical Sciences and the Bioinformatics Research Center at NCSU. 

More information is available from the BRC and from Tex…

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Impact of Low Dose Oral Exposure to Bisphenol A (BPA) on Juvenile and Adult Rat Exploratory and Anxiety Behavior: A CLARITY-BPA Consortium Study (2015) Toxicological Sciences

July 23, 2015

Rebuli, Camacho, Adonay, Reif, Aylor, Patisaul. Impact of Low Dose Oral Exposure to Bisphenol A (BPA) on Juvenile and Adult Rat Exploratory and Anxiety Behavior: A CLARITY-BPA Consortium Study. (2015) Toxicological Sciences.

http://www.ncbi.nlm.nih.gov/pubmed/26209558

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Reif named Managing Editor of journal BioData Mining

July 13, 2015

David Reif has been named the new Managing Editor of the journal BioData Mining 

BioData Mining is an open-access, peer-reviewed, online journal encompassing research on all aspects of data mining applied to high-dimensional biological and biomedical data, focusing on computational aspects o…

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Toxicity testing in the 21st century beyond environmental chemicals (2015) Altex

July 10, 2015

Costanza Rovida, Shoji Asakura, Mardas Daneshian, Hana Hofman-Huether, Marcel Leist, Leo Meunier, David Reif, Anna Rossi, Markus Schmutz, Jean-Pierre Valentin, Joanne Zurlo, Thomas Hartung.Toxicity testing in the 21st century beyond environmental chemicals. (2015) Altex 32 (3), 171-181.

http://w…

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High-throughput characterization of chemical-associated embryonic behavioral changes predicts teratogenic outcomes (2015) Archives of Toxicology

July 1, 2015

High-throughput characterization of chemical-associated embryonic behavioral changes predicts teratogenic outcomes (2015) Archives of Toxicology

http://www.ncbi.nlm.nih.gov/pubmed/26126630

(NOTE: Full-text available for free via link above or here)

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Reif serves on expert Working Group for the World Health Organization's (WHO) International Agency for Cancer Research (IARC)

June 23, 2015

David Reif was a member of the Working Group that drew experts from 13 countries to a meeting in Lyon, France in order to evaluate the carcinogenicity of the the insecticides gamma-hexachlorocyclohexane (lindane) and dichlorodiphenyltrichloroethane (DDT) and the herbicide 2,4-dichlorophenoxyacetic a…

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20 blog posts