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Blog posts : "Publications"

Synergistic chemotherapy drug response is a genetic trait in lymphoblastoid cell lines (2019) Frontiers in Genetics

Kyle Roell, Tammy Havener, David Reif*, John Jack, Howard McLeod, Tim Wiltshire, Alison Motsinger-Reif*

Front. Genet. | doi: 10.3389/fgene.2019.00829

Synergistic chemotherapy drug response is a genetic trait in lymphoblastoid cell lines

Lymphoblastoid cell lines (LCL) are a high…

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Population-based toxicity screening in human induced pluripotent stem cell-derived cardiomyocytes (2019) Toxicol Appl Pharmacol

Burnett SD, Blanchette AD, Grimm FA, House JS, Reif DM, Wright FA, Chiu WA,
Rusyn I. Population-based toxicity screening in human induced pluripotent stem
cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Aug 16;381:114711. doi:
10.1016/j.taap.2019.114711. [Epub ahead of print] PubMed P…

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Knockdown of arylalkylamine N-acetyltransferase-like 2 in Drosophila melanogaster (2019) Arch Insect Biochem Physiol

Anderson RL, Wallis DJ, Aguirre A, Holliday D, Merkler DJ. Knockdown of
arylalkylamine N-acetyltransferase-like 2 in Drosophila melanogaster. Arch Insect
Biochem Physiol. 2019 Aug 6:e21608. doi: 10.1002/arch.21608. [Epub ahead of
print] PubMed PMID: 31385627.

 

https://www.ncbi.nlm.nih.g…

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Determination of chemical-disease risk values to prioritize connections between environmental factors, genetic variants, and human diseases (2019) Toxicology and Applied Pharmacology

Kosnik MB, Reif DM. Determination of chemical-disease risk values to
prioritize connections between environmental factors, genetic variants, and human
diseases. Toxicol Appl Pharmacol. 2019 Jul 16:114674. doi:
10.1016/j.taap.2019.114674. [Epub ahead of print] PubMed PMID: 31323264.

Integration of curated and high-throughput screening data to elucidate environmental influences on disease pathways (2019) Computational Toxicology

Vaccines and science communication

A recent article by Sarah Zhang in The Atlantic illustrates the importance of science communication with regard to vaccinomics:

https://www.theatlantic.com/science/archive/2019/05/vaccines-dna-23andme/589915/

 

Part of that article details how one of our past papers has been interpreted, …

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Reif co-authors National Academy of Sciences (NAS) report "A Class Approach to Hazard Assessment of Organohalogen Flame Retardants"

Systematic determination of the relationship between nanoparticle core diameter and toxicity for a series of structurally analogous gold nanoparticles in zebrafish (2019) Nanotoxicology

https://www.tandfonline.com/doi/full/10.1080/17435390.2019.1592259

 

Truong, L.; Zaikova, T.; Baldock, B.L.; Balik-Meisner, M.; To, K.; Reif, D.M.; Kennedy, Z.C.; Hutchison, J.E.; Tanguay, R.L. “Systematic determination of the relationship between nanoparticle core diameter and toxicity for a…

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Associations between access to healthcare, environmental quality, and end-stage renal disease survival time: Proportional-hazards models of over 1,000,000 people over 14 years (2019) PLoS One

Kosnik MB, Reif DM, Lobdell DT, Astell-Burt T, Feng X, Hader JD, Hoppin JA.
Associations between access to healthcare, environmental quality, and end-stage
renal disease survival time: Proportional-hazards models of over 1,000,000 people
over 14 years. PLoS One. 2019 Mar 21;14(3):e0214094. doi:…

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Neonatal mice exposed to a high-fat diet in utero influence the behaviour of their nursing dam (2018) Proc R Sci B

Neonatal mice exposed to a high-fat diet in utero influence the behaviour of their nursing dam.

Baptissart M, Lamb HE, To K, Bradish C, Tehrani J, Reif D, Cowley M.

Proc Biol Sci. 2018 Nov 14;285(1891). pii: 20181237. doi: 10.1098/rspb.2018.1237.

PMID: 30429298

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GxE publication named an NIEHS "Paper of the Month"

Michele's paper "Elucidating gene-by-environment interactions associated with differential susceptibility to chemical exposure" was cited in the NIEHS newsletter as a Paper of the Month!

https://factor.niehs.nih.gov/2018/9/papers/dert/index.htm

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Bm-iAANAT and its potential role in fatty acid amide biosynthesis in Bombyx mori (2018) Prostaglandins Leukot Essent Fatty Acids

Anderson RL, Battistini MR, Wallis DJ, Shoji C, O'Flynn BG, Dillashaw JE,
Merkler DJ. Bm-iAANAT and its potential role in fatty acid amide biosynthesis in 
Bombyx mori. Prostaglandins Leukot Essent Fatty Acids. 2018 Aug;135:10-17. doi:
10.1016/j.plefa.2018.06.001. Epub 2018 Jun 15. PubMed PMID:…

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Elucidating Gene-by-Environment Interactions Associated with Differential Susceptibility to Chemical Exposure (2018) EHP

Full paper:

https://ehp.niehs.nih.gov/EHP2662/

PubMed:

https://www.ncbi.nlm.nih.gov/pubmed/29968567

News releases and press coverage:

https://news.ncsu.edu/2018/06/reif-genes-environment/

https://www.sciencedaily.com/releases/2018/06/180629114700.htm
 
https://globalhealthnewswire.com/2018/…

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Characterizing the effects of missing data and evaluating imputation methods for chemical prioritization applications using ToxPi (2018) BioData Mining

Kimberly T. To, Rebecca C. Fry, David M. Reif. Characterizing the effects of missing data and evaluating imputation methods for chemical prioritization applications using ToxPi. BioData Mining. 2018. 

https://rdcu.be/XYtJ

 

Confirmation of high-throughput screening data and novel mechanistic insights into VDR-xenobiotic interactions by orthogonal assays (2018) Scientific Reports

Mahapatra D, Franzosa JA, Roell K, Kuenemann MA, Houck KA, Reif DM, Fourches
D, Kullman SW. Confirmation of high-throughput screening data and novel
mechanistic insights into VDR-xenobiotic interactions by orthogonal assays. Sci
Rep. 2018 Jun 11;8(1):8883. doi: 10.1038/s41598-018-27055-3. PubMe…

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ToxPi Graphical User Interface 2.0: Dynamic exploration, visualization, and sharing of integrated data models (2018) BMC Bioinformatics

Marvel SW, To K, Grimm FA, Wright FA, Rusyn I, Reif DM. ToxPi Graphical User Interface 2.0: Dynamic exploration, visualization, and sharing of integrated data models. BMC Bioinformatics. 2018 Mar 5;19(1):80. doi: 10.1186/s12859-018-2089-2. PubMed PMID: 29506467.

 

https://bmcbioinformatics.bi…

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Population genetic diversity in zebrafish lines (2018) Mammalian Genome

Balik-Meisner M, Truong L, Scholl EH, Tanguay RL, Reif DM. Population genetic 
diversity in zebrafish lines. Mamm Genome. 2018 Jan 24. doi:
10.1007/s00335-018-9735-x. [Epub ahead of print] PubMed PMID: 29368091.

https://www.ncbi.nlm.nih.gov/pubmed/29368091

 

 

 

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Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups (2017) ALTEX

Transgenerational inheritance of neurobehavioral and physiological deficits from developmental exposure to benzo [a] pyrene in zebrafish (2017) Toxicology and Applied Pharmacology

Knecht AL, Truong L, Marvel SW, Reif DM, Garcia A, Lu C, Simonich MT,
Teeguarden JG, Tanguay RL. Transgenerational inheritance of neurobehavioral and
physiological deficits from developmental exposure to benzo[a]pyrene in
zebrafish. Toxicol Appl Pharmacol. 2017 Jun 3;329:148-157. doi:
10.1016/…

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An introduction to terminology and methodology of chemical synergy -perspectives from across disciplines (2017) Frontiers in Pharmacology

20 blog posts