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Determination of chemical-disease risk values to prioritize connections between environmental factors, genetic variants, and human diseases (2019) Toxicology and Applied Pharmacology

Kosnik MB, Reif DM. Determination of chemical-disease risk values to
prioritize connections between environmental factors, genetic variants, and human
diseases. Toxicol Appl Pharmacol. 2019 Jul 16:114674. doi:
10.1016/j.taap.2019.114674. [Epub ahead of print] PubMed PMID: 31323264.

Dr. Adrian Green joins the Reif Lab!

Dr. Adrian Green is a Postdoctoral Research Scholar in the Bioinformatics Research Center at NC State University. He received his Ph.D. in Toxicology at NC State University, and his M.S. in Pharmacology and Toxicology at the University of California, Davis. He received his B.S. in Microbiology (mino…

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Integration of curated and high-throughput screening data to elucidate environmental influences on disease pathways (2019) Computational Toxicology

NIH / NIEHS grant "Gene-Environment Interactions Causing Differential Susceptibility to Chemical Exposure in High-Throughput Screening"

Vaccines and science communication

A recent article by Sarah Zhang in The Atlantic illustrates the importance of science communication with regard to vaccinomics:

https://www.theatlantic.com/science/archive/2019/05/vaccines-dna-23andme/589915/

 

Part of that article details how one of our past papers has been interpreted, …

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Joint retreat in Oregon with Tanguay + Reif labs

The Tanguay + Reif labs met in Oregon for their second joint retreat. 

The retreat started with scientific sessions and lab tours at Oregon State University and the Sinnhuber Aquatic Research Lab (SARL) in Corvallis. We then moved to the Oregon Coast for more scientific sessions, hiking, and int…

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Reif co-authors National Academy of Sciences (NAS) report "A Class Approach to Hazard Assessment of Organohalogen Flame Retardants"

EPA grant "System toxicological approaches to define and predict the toxicity of Per and Polyfluoroalkyl Substances"

https://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.abstractDetail/abstract/10950/report/0

 

System toxicological approaches to define and predict the toxicityofPerand Polyfluoroalkyl Substances

EPA Grant Number: R839481
Title: System toxicological approaches to define and …

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Preethi Thunga joins the Reif Lab!

Bio

Preethi is pursuing her PhD in the Bioinformatics graduate program.

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Marissa Kosnik successfully defends her PhD!

Title - Data integration elucidates connections between environmental factors and health outcomes
 
Abstract : It is well understood that environmental factors contribute to the development of human diseases. Multiple types and sources of data are necessary to address the complex relationsh…

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Systematic determination of the relationship between nanoparticle core diameter and toxicity for a series of structurally analogous gold nanoparticles in zebrafish (2019) Nanotoxicology

https://www.tandfonline.com/doi/full/10.1080/17435390.2019.1592259

 

Truong, L.; Zaikova, T.; Baldock, B.L.; Balik-Meisner, M.; To, K.; Reif, D.M.; Kennedy, Z.C.; Hutchison, J.E.; Tanguay, R.L. “Systematic determination of the relationship between nanoparticle core diameter and toxicity for a…

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ToxPi software updated (v2.2) @ www.toxpi.org

The complete .zip is available for free download at: www.toxpi.org

This update adds flexibility for setting weights, offers improved "zoom" capabilities, updates information included in the saved Results Table object, and fixes issues identified by users.

The updated manual includes a full …

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Associations between access to healthcare, environmental quality, and end-stage renal disease survival time: Proportional-hazards models of over 1,000,000 people over 14 years (2019) PLoS One

Kosnik MB, Reif DM, Lobdell DT, Astell-Burt T, Feng X, Hader JD, Hoppin JA.
Associations between access to healthcare, environmental quality, and end-stage
renal disease survival time: Proportional-hazards models of over 1,000,000 people
over 14 years. PLoS One. 2019 Mar 21;14(3):e0214094. doi:…

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Kim To successfully defends her PhD!

Title: Predictive modeling for developmental toxicity of engineered nanomaterials.
 
Abstract: Nanomaterials are defined as particles with at least one dimension on the nanoscale (1-100nm). Although their toxicity is not yet fully understood, nanomaterials present themselves in a wide varie…

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Marissa presents at UNC Environmental Epidemiology Seminar Series

Kosnik M.B., Reif D.M., Lobdell D.T., Astell-Burt T., Feng X., Hader J.D., Hoppin J.A. Associations between access to healthcare, environmental quality, and end-stage renal disease survival time: proportional-hazards models of over 1,000,000 people over 14 years. (manuscript submitted/in revision)

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Marissa presents at U.S. EPA ToxCast Meeting

The seminar was in relation to the forthcoming paper by Kosnik et al. "Concentration-Response Evaluation of ToxCast Compounds for Multivariate Fingerprints of Neural Network Function"

Dylan Wallis joins the Reif Lab!

Bio

Dylan is pursuing his PhD in the Toxicology graduate program.

Reif teaches short course with Ken Rice (University of Washington) at NYU Abu Dhabi's Winter Institute of Statistical Genetics

More information, including registration details and the list of fellow instructors can be found here:

https://nyuadi.secure.force.com/Events/NYUEventRegistration?event=U9fzrcAHenY2P0df1GzIyQ_3D_3D 

Reif gives invited seminar at Paris symposium

The workshop, "Fish and amphibian embryos as alternative models in toxicology and teratology" was organized by the Helmholtz Centre for Environmental Research and hosted at L'Oréal headquarters in Paris, France. 

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Neonatal mice exposed to a high-fat diet in utero influence the behaviour of their nursing dam (2018) Proc R Sci B

Neonatal mice exposed to a high-fat diet in utero influence the behaviour of their nursing dam.

Baptissart M, Lamb HE, To K, Bradish C, Tehrani J, Reif D, Cowley M.

Proc Biol Sci. 2018 Nov 14;285(1891). pii: 20181237. doi: 10.1098/rspb.2018.1237.

PMID: 30429298

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20 blog posts