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Sex-specific effects of perinatal FireMaster® 550 (FM 550) exposure on socioemotional behavior in prairie voles (2019) Neurotoxicology and Teratology

Gillera SEA, Marinello WP, Horman BM, Phillips AL, Ruis MT, Stapleton HM, Reif
DM, Patisaul HB. Sex-specific effects of perinatal FireMaster® 550 (FM 550)
exposure on socioemotional behavior in prairie voles. Neurotoxicol Teratol. 2019 
Nov 12:106840. doi: 10.1016/j.ntt.2019.106840. [Epub ahead…

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Multivariate modeling of engineered nanomaterial features associated with developmental toxicity (2019) NanoImpact

 

KT To, L Truong, S Edwards, RL Tanguay, DM Reif (2019) Multivariate modeling of engineered nanomaterial features associated with developmental toxicity, NanoImpact.

 

 

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Marissa wins award for presentation at International Neurotoxicology Association meeting in Germany

Marissa Kosnik won an INA student poster award for her poster presentation at the International Neurotoxicology Association meeting in Dusseldorf, Germany.

Melody Hancock joins the Reif Lab!

Melody Hancock is a Master of Physiology student at NC State University. She received her B.S. in Biochemistry and Molecular Biology, with a double major in Spanish, from Mercer University in Macon, GA. Her research focuses on methods for optimizing multivariate profiling methods, such as ToxPi, for…

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David presents at INA meeting in Germany

David presented a platform presentation at the at the International Neurotoxicology Association meeting in Dusseldorf, Germany. 

David's talked was entitled "The power of data integration for systems neurotoxicology".  It was given as part of the  session "Systems neurotoxicology: From in v…

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Synergistic chemotherapy drug response is a genetic trait in lymphoblastoid cell lines (2019) Frontiers in Genetics

Kyle Roell, Tammy Havener, David Reif*, John Jack, Howard McLeod, Tim Wiltshire, Alison Motsinger-Reif*

Front. Genet. | doi: 10.3389/fgene.2019.00829

Synergistic chemotherapy drug response is a genetic trait in lymphoblastoid cell lines

Lymphoblastoid cell lines (LCL) are a high…

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Population-based toxicity screening in human induced pluripotent stem cell-derived cardiomyocytes (2019) Toxicol Appl Pharmacol

Burnett SD, Blanchette AD, Grimm FA, House JS, Reif DM, Wright FA, Chiu WA,
Rusyn I. Population-based toxicity screening in human induced pluripotent stem
cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Aug 16;381:114711. doi:
10.1016/j.taap.2019.114711. [Epub ahead of print] PubMed P…

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Knockdown of arylalkylamine N-acetyltransferase-like 2 in Drosophila melanogaster (2019) Arch Insect Biochem Physiol

Anderson RL, Wallis DJ, Aguirre A, Holliday D, Merkler DJ. Knockdown of
arylalkylamine N-acetyltransferase-like 2 in Drosophila melanogaster. Arch Insect
Biochem Physiol. 2019 Aug 6:e21608. doi: 10.1002/arch.21608. [Epub ahead of
print] PubMed PMID: 31385627.

 

https://www.ncbi.nlm.nih.g…

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Determination of chemical-disease risk values to prioritize connections between environmental factors, genetic variants, and human diseases (2019) Toxicology and Applied Pharmacology

Kosnik MB, Reif DM. Determination of chemical-disease risk values to
prioritize connections between environmental factors, genetic variants, and human
diseases. Toxicol Appl Pharmacol. 2019 Jul 16:114674. doi:
10.1016/j.taap.2019.114674. [Epub ahead of print] PubMed PMID: 31323264.

Dr. Adrian Green joins the Reif Lab!

Dr. Adrian Green is a Postdoctoral Research Scholar in the Bioinformatics Research Center at NC State University. He received his Ph.D. in Toxicology at NC State University, and his M.S. in Pharmacology and Toxicology at the University of California, Davis. He received his B.S. in Microbiology (mino…

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Integration of curated and high-throughput screening data to elucidate environmental influences on disease pathways (2019) Computational Toxicology

NIH / NIEHS grant "Gene-Environment Interactions Causing Differential Susceptibility to Chemical Exposure in High-Throughput Screening"

Vaccines and science communication

A recent article by Sarah Zhang in The Atlantic illustrates the importance of science communication with regard to vaccinomics:

https://www.theatlantic.com/science/archive/2019/05/vaccines-dna-23andme/589915/

 

Part of that article details how one of our past papers has been interpreted, …

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Joint retreat in Oregon with Tanguay + Reif labs

The Tanguay + Reif labs met in Oregon for their second joint retreat. 

The retreat started with scientific sessions and lab tours at Oregon State University and the Sinnhuber Aquatic Research Lab (SARL) in Corvallis. We then moved to the Oregon Coast for more scientific sessions, hiking, and int…

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Reif co-authors National Academy of Sciences (NAS) report "A Class Approach to Hazard Assessment of Organohalogen Flame Retardants"

EPA grant "System toxicological approaches to define and predict the toxicity of Per and Polyfluoroalkyl Substances"

https://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.abstractDetail/abstract/10950/report/0

 

System toxicological approaches to define and predict the toxicityofPerand Polyfluoroalkyl Substances

EPA Grant Number: R839481
Title: System toxicological approaches to define and …

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Preethi Thunga joins the Reif Lab!

Bio

Preethi is pursuing her PhD in the Bioinformatics graduate program.

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Marissa Kosnik successfully defends her PhD!

Title - Data integration elucidates connections between environmental factors and health outcomes
 
Abstract : It is well understood that environmental factors contribute to the development of human diseases. Multiple types and sources of data are necessary to address the complex relationsh…

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Systematic determination of the relationship between nanoparticle core diameter and toxicity for a series of structurally analogous gold nanoparticles in zebrafish (2019) Nanotoxicology

https://www.tandfonline.com/doi/full/10.1080/17435390.2019.1592259

 

Truong, L.; Zaikova, T.; Baldock, B.L.; Balik-Meisner, M.; To, K.; Reif, D.M.; Kennedy, Z.C.; Hutchison, J.E.; Tanguay, R.L. “Systematic determination of the relationship between nanoparticle core diameter and toxicity for a…

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ToxPi software updated (v2.2) @ www.toxpi.org

The complete .zip is available for free download at: www.toxpi.org

This update adds flexibility for setting weights, offers improved "zoom" capabilities, updates information included in the saved Results Table object, and fixes issues identified by users.

The updated manual includes a full …

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20 blog posts