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Blog posts : "david reif"

Synergistic chemotherapy drug response is a genetic trait in lymphoblastoid cell lines (2019) Frontiers in Genetics

Kyle Roell, Tammy Havener, David Reif*, John Jack, Howard McLeod, Tim Wiltshire, Alison Motsinger-Reif*

Front. Genet. | doi: 10.3389/fgene.2019.00829

Synergistic chemotherapy drug response is a genetic trait in lymphoblastoid cell lines

Lymphoblastoid cell lines (LCL) are a high…

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Population-based toxicity screening in human induced pluripotent stem cell-derived cardiomyocytes (2019) Toxicol Appl Pharmacol

Burnett SD, Blanchette AD, Grimm FA, House JS, Reif DM, Wright FA, Chiu WA,
Rusyn I. Population-based toxicity screening in human induced pluripotent stem
cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Aug 16;381:114711. doi:
10.1016/j.taap.2019.114711. [Epub ahead of print] PubMed P…

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Determination of chemical-disease risk values to prioritize connections between environmental factors, genetic variants, and human diseases (2019) Toxicology and Applied Pharmacology

Kosnik MB, Reif DM. Determination of chemical-disease risk values to
prioritize connections between environmental factors, genetic variants, and human
diseases. Toxicol Appl Pharmacol. 2019 Jul 16:114674. doi:
10.1016/j.taap.2019.114674. [Epub ahead of print] PubMed PMID: 31323264.

Integration of curated and high-throughput screening data to elucidate environmental influences on disease pathways (2019) Computational Toxicology

NIH / NIEHS grant "Gene-Environment Interactions Causing Differential Susceptibility to Chemical Exposure in High-Throughput Screening"

Joint retreat in Oregon with Tanguay + Reif labs

The Tanguay + Reif labs met in Oregon for their second joint retreat. 

The retreat started with scientific sessions and lab tours at Oregon State University and the Sinnhuber Aquatic Research Lab (SARL) in Corvallis. We then moved to the Oregon Coast for more scientific sessions, hiking, and int…

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Reif co-authors National Academy of Sciences (NAS) report "A Class Approach to Hazard Assessment of Organohalogen Flame Retardants"

Reif gives invited seminar at Paris symposium

The workshop, "Fish and amphibian embryos as alternative models in toxicology and teratology" was organized by the Helmholtz Centre for Environmental Research and hosted at L'Oréal headquarters in Paris, France. 

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Characterizing the effects of missing data and evaluating imputation methods for chemical prioritization applications using ToxPi (2018) BioData Mining

Kimberly T. To, Rebecca C. Fry, David M. Reif. Characterizing the effects of missing data and evaluating imputation methods for chemical prioritization applications using ToxPi. BioData Mining. 2018. 

https://rdcu.be/XYtJ

 

Reif appointed to National Academy of Sciences (NAS) committee

Scoping Plan to Assess the Hazards of Organohalogen Flame Retardants 

https://www8.nationalacademies.org/cp/CommitteeView.aspx?key=49937

Confirmation of high-throughput screening data and novel mechanistic insights into VDR-xenobiotic interactions by orthogonal assays (2018) Scientific Reports

Mahapatra D, Franzosa JA, Roell K, Kuenemann MA, Houck KA, Reif DM, Fourches
D, Kullman SW. Confirmation of high-throughput screening data and novel
mechanistic insights into VDR-xenobiotic interactions by orthogonal assays. Sci
Rep. 2018 Jun 11;8(1):8883. doi: 10.1038/s41598-018-27055-3. PubMe…

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Kyle Roell successfully defends his PhD!

Kyle Roell successfully defended his PhD, entitled "Statistical Methods for Assessing the Genetic Etiology of Synergistic Drug Interactions".

Dr. Kyle Roell is currently a postdoc with Stephanie Engel in the Department of Epidemiology at UNC Chapel Hill.

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National Academies meeting: "Informing Environmental Health Decisions Through Data Integration"

David Reif was a moderator and member of the planning committee for the National Academy of Sciences workshop "Informing Environmental Health Decisions Through Data Integration". 

The workshop brought together thought leaders from diverse fields to explore the promise and potential pitfalls of e…

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Population genetic diversity in zebrafish lines (2018) Mammalian Genome

Balik-Meisner M, Truong L, Scholl EH, Tanguay RL, Reif DM. Population genetic 
diversity in zebrafish lines. Mamm Genome. 2018 Jan 24. doi:
10.1007/s00335-018-9735-x. [Epub ahead of print] PubMed PMID: 29368091.

https://www.ncbi.nlm.nih.gov/pubmed/29368091

 

 

 

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Flash Report: SEAZIT Ontologies Workshop

A report on the SEAZIT (Systematic Evaluation of the Application of Zebrafish in Toxicology) Ontologies Workshop has been published:

https://ntp.niehs.nih.gov/iccvam/methods/dev-repro/ontologies-wksp-rept-2017.pdf

Reif serves as Working Group member for the World Health Organization's (WHO) International Agency for Research on Cancer (IARC) monograph on Benzene

David Reif was a member of the Working Group that drew experts from around the world to a meeting in Lyon, France in order to evaluate the carcinogenicity of Benzene. 

Summaries of the final evaluations are available in the Lancet Oncology article. The detailed assessments will be published as …

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Transgenerational inheritance of neurobehavioral and physiological deficits from developmental exposure to benzo [a] pyrene in zebrafish (2017) Toxicology and Applied Pharmacology

Knecht AL, Truong L, Marvel SW, Reif DM, Garcia A, Lu C, Simonich MT,
Teeguarden JG, Tanguay RL. Transgenerational inheritance of neurobehavioral and
physiological deficits from developmental exposure to benzo[a]pyrene in
zebrafish. Toxicol Appl Pharmacol. 2017 Jun 3;329:148-157. doi:
10.1016/…

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Reif presents at International Neurotoxicology Association meeting in Brazil

David Reif presented at the joint meeting of the International Neurotoxicology Association & Neurotoxicity Society in Florianopolis, Brazil. 

The seminar was entitled "Developing an Integrated Testing Strategy: Analytical methods to distill useful information from high-throughput screening of ch…

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An introduction to terminology and methodology of chemical synergy -perspectives from across disciplines (2017) Frontiers in Pharmacology

Integrating Morphological and Behavioral Phenotypes in Developing Zebrafish

Zhang G., Truong L., Tanguay R.L., Reif D.M. (2017) Integrating Morphological and Behavioral Phenotypes in Developing Zebrafish. In: Kalueff A. (eds) The rights and wrongs of zebrafish: Behavioral phenotyping of zebrafish. Springer, Cham.

http://www.springer.com/us/book/9783319337739

https://l…

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